The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 30, 2015

Filed:

Jul. 26, 2013
Applicants:

The United States of America As Represented BY the Secretary of the Department of Health and Human Services, Washington, DC (US);

The University of Dundee, Dundee, GB;

Masaryk Memorial Cancer Institute, Brno, CZ;

Inventors:

Curtis C. Harris, Garrett Park, MD (US);

Kaori Fujita, Kyoto, JP;

Izumi Horikawa, Rockville, MD (US);

Borivoj Vojtesek, Modrice, CZ;

Jean-Christophe Bourdon, Dundee, GB;

David P. Lane, Singapore, SG;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/077 (2010.01); A61K 31/7105 (2006.01); A61K 31/711 (2006.01); A61K 31/713 (2006.01); C07K 14/47 (2006.01); C12N 15/113 (2010.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0652 (2013.01); A61K 31/7105 (2013.01); A61K 31/711 (2013.01); A61K 31/713 (2013.01); A61K 48/00 (2013.01); C07K 14/4746 (2013.01); C12N 15/1135 (2013.01); C12N 2310/11 (2013.01); C12N 2310/12 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01);
Abstract

The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.


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