The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2015
Filed:
Jan. 25, 2013
Applicants:
Claudio Bordignon, Milan, IT;
Antonio Lambiase, Milan, IT;
Inventors:
Claudio Bordignon, Milan, IT;
Antonio Lambiase, Milan, IT;
Assignee:
Molmed S.P.A, Milan, IT;
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/19 (2006.01); A61K 38/08 (2006.01); A61K 38/10 (2006.01); A61K 38/12 (2006.01); C07K 14/25 (2006.01); C07K 7/64 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/525 (2006.01); A61K 38/20 (2006.01); A61K 38/21 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
C07K 14/525 (2013.01); A61K 38/191 (2013.01); A61K 38/208 (2013.01); A61K 38/217 (2013.01); A61K 47/48246 (2013.01); C07K 7/06 (2013.01);
Abstract
The present invention provides conjugates of cytokines and targeting peptides that is able to bind to a receptor expressed on tumor-associated vessels or to a component of the extracellular matrix associated to the tumor vessels, for treatment of malignant pleural mesothelioma. In particular, the invention provides conjugates comprising the cytokine TNF linked to a peptide containing the NGR motif. The invention further provides pharmaceutical compositions comprising such conjugate and pharmaceutical formulations comprising conjugates dissolved in appropriate buffers.