The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2015
Filed:
Oct. 29, 2009
Guriqbal Basi, Palo Alto, CA (US);
Dale B. Schenk, Burlingame, CA (US);
Hadar Hana Feinberg, Los Altos, CA (US);
William I. Weis, Palo Alto, CA (US);
Guriqbal Basi, Palo Alto, CA (US);
Dale B. Schenk, Burlingame, CA (US);
Hadar Hana Feinberg, Los Altos, CA (US);
William I. Weis, Palo Alto, CA (US);
JANSSEN SCIENCES IRELAND UC, , IE;
WYETH LLC, Madison, NJ (US);
THE BOARD OF TRUSTEES OF LELAND STANFORD JR. UNIVERSITY, Stanford, CA (US);
Abstract
The present invention provides crystals including amino acids 1-7 of SEQ ID NO:1 and a Fab fragment of 12A11, 12B4, 10D5 or 3D6, as well as of amino acids 1-40 of SEQ ID NO:1 and a Fab fragment of 12A11 or 3D6, as well as methods for preparing the crystals. The present invention also provides a computer implemented method for analyzing binding of a candidate antibody fragment to a peptide including an epitope of amino acids 1-7 of SEQ ID NO:1, a method for identifying an antibody fragment that can mimic the Fab fragment of 12A11, a method for identifying an antibody fragment that can mimic the Fab fragment of 3D6, a method for identifying a candidate antibody fragment that binds to a peptide including an epitope of amino acids 1-7 of SEQ ID NO:1, and a method for designing a humanized antibody that binds to a peptide comprising an epitope of amino acids 1-7 of SEQ ID NO:1.