The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 30, 2015

Filed:

Mar. 04, 2011
Applicants:

H. Randall Bell, Arlington, VA (US);

John W Pettit, Derwood, MD (US);

James P Landers, Charlottesville, VA (US);

Joan M Bienvenue, Fredericksburg, VA (US);

Daniel J Marchiarullo, North Haledon, NJ (US);

Brian E Root, Charlottesville, VA (US);

Orion N Scott, Charlottesville, VA (US);

Inventors:

H. Randall Bell, Arlington, VA (US);

John W Pettit, Derwood, MD (US);

James P Landers, Charlottesville, VA (US);

Joan M Bienvenue, Fredericksburg, VA (US);

Daniel J Marchiarullo, North Haledon, NJ (US);

Brian E Root, Charlottesville, VA (US);

Orion N Scott, Charlottesville, VA (US);

Assignees:

UNIVERSITY OF VIRGINIA PATENT FOUNDATION, Charlottesville, VA (US);

ZYGEM CORPORATION LTD., Hamilton, NZ;

Lockheed Martin Corporation, Bethesda, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); B01L 3/00 (2006.01); B01L 7/00 (2006.01); G01N 27/447 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502753 (2013.01); B01L 7/525 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/087 (2013.01); B01L 2400/0421 (2013.01); G01N 27/44791 (2013.01);
Abstract

Aspects of the disclosure provides a DNA analyzer to facilitate an integrated single-chip DNA analysis. The DNA analyzer includes an interface for coupling a microfluidic chip to the DNA analyzer. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain fluidically coupled to the first domain to receive the DNA fragments and perform electrophoretic separation of the DNA fragments. The DNA fragments are tagged with fluorescent labels. The DNA analyzer includes a detection module to excite the fluorescent labels to emit fluorescence and detect the emitted fluorescence. The detection module includes a laser source, a set of optical elements, a filter module and a photo-detector.


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