The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2015
Filed:
Feb. 20, 2013
Applicant:
Bristol-myers Squibb Company, Tokyo, JP;
Inventors:
Margaret M. Gleeson, Berkeley Heights, NJ (US);
Soojin Kim, Demarest, NJ (US);
Donald C. Kientzler, Hightstown, NJ (US);
San Kiang, Madison, NJ (US);
Assignee:
Otsuka Pharmaceuticals Co., Ltd., Tokyo, JP;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61J 3/02 (2006.01); C07D 215/227 (2006.01); B01D 9/00 (2006.01); B01J 2/06 (2006.01);
U.S. Cl.
CPC ...
A61J 3/02 (2013.01); B01D 9/0009 (2013.01); B01D 9/0054 (2013.01); B01D 9/0081 (2013.01); B01J 2/06 (2013.01); C07D 215/227 (2013.01);
Abstract
A process is provided for making sterile aripiprazole having an average particle size less than 100 microns but preferably greater than 25 microns employing an impinging jet crystallization procedure. The resulting bulk aripiprazole of desired particle size may be used to form a sterile freeze-dried aripiprazole formulation, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks.