The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 23, 2015

Filed:

Jul. 30, 2010
Applicants:

Samad Talebpour, Richmond Hill, CA;

Aye Aye Khine, Thornhill, CA;

Stephen W. Leonard, Unionville, CA;

Robert Maaskant, King City, CA;

Tino Alavie, Thornhill, CA;

Inventors:

Samad Talebpour, Richmond Hill, CA;

Aye Aye Khine, Thornhill, CA;

Stephen W. Leonard, Unionville, CA;

Robert Maaskant, King City, CA;

Tino Alavie, Thornhill, CA;

Assignee:

QVELLA CORPORATION, Richmond Hill, ON, CA;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/543 (2006.01); B01L 3/00 (2006.01); C12M 3/06 (2006.01); C12M 1/12 (2006.01); C12M 1/00 (2006.01); C12M 1/42 (2006.01); C12M 1/34 (2006.01); C12N 1/06 (2006.01); C12N 11/14 (2006.01); C12N 13/00 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5438 (2013.01); B01L 3/502715 (2013.01); B01L 3/502753 (2013.01); C12M 23/16 (2013.01); C12M 25/00 (2013.01); C12M 25/04 (2013.01); C12M 29/10 (2013.01); C12M 35/02 (2013.01); C12M 41/38 (2013.01); C12N 1/066 (2013.01); C12N 11/14 (2013.01); C12N 13/00 (2013.01); G01N 33/5005 (2013.01);
Abstract

The present invention provides a microfluidic devices and methods of use thereof for the concentration and capture of cells. A pulsed non-Faradaic electric field is applied relative to a sample under laminar flow, which results to the concentration and capture of charged analyte. Advantageously, pulse timing is selected to avoid problems associated with ionic screening within the channel. At least one of the electrodes within the channel is coated with an insulating layer to prevent a Faradaic current from flowing in the channel. Under pulsed application of a unipolar voltage to the electrodes, charged analyte within the sample is moved towards one of the electrodes via a transient electrophoretic force.


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