The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 23, 2015

Filed:

Nov. 10, 2008
Applicants:

Richard Weber, San Francisco, CA (US);

Xiao Feng, Elk Grove, CA (US);

Orit Foord, Foster City, CA (US);

Larry Green, San Francisco, CA (US);

Jean Gudas, Los Angeles, CA (US);

Bruce Keyt, Hillsborough, CA (US);

Ying Liu, Palo Alto, CA (US);

Palaniswami Rathanaswami, Vancouver, CA;

Robert Raya, Fremont, CA (US);

Xiao Dong Yang, Palo Alto, CA (US);

Jose Corvalan, Foster City, CA (US);

Ian Foltz, Burnaby, CA;

Xiao-chi Jia, Los Angeles, CA (US);

Jaspal S. Kang, Surrey, CA;

Chadwick T. King, North Vancouver, CA;

Scott L. Klakamp, Fremont, CA (US);

Qiaojuan Jane Su, San Jose, CA (US);

Inventors:

Richard Weber, San Francisco, CA (US);

Xiao Feng, Elk Grove, CA (US);

Orit Foord, Foster City, CA (US);

Larry Green, San Francisco, CA (US);

Jean Gudas, Los Angeles, CA (US);

Bruce Keyt, Hillsborough, CA (US);

Ying Liu, Palo Alto, CA (US);

Palaniswami Rathanaswami, Vancouver, CA;

Robert Raya, Fremont, CA (US);

Xiao Dong Yang, Palo Alto, CA (US);

Jose Corvalan, Foster City, CA (US);

Ian Foltz, Burnaby, CA;

Xiao-Chi Jia, Los Angeles, CA (US);

Jaspal S. Kang, Surrey, CA;

Chadwick T. King, North Vancouver, CA;

Scott L. Klakamp, Fremont, CA (US);

Qiaojuan Jane Su, San Jose, CA (US);

Assignee:

Amgen Fremont Inc., Fremont, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/08 (2006.01); C07K 16/28 (2006.01); C07K 14/705 (2006.01); A61K 47/48 (2006.01); B82Y 5/00 (2011.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); A61K 2039/505 (2013.01); Y10S 435/81 (2013.01); A61K 47/48384 (2013.01); B82Y 5/00 (2013.01); A61K 47/48746 (2013.01); C07K 2317/34 (2013.01); A61K 47/48561 (2013.01); C07K 2317/92 (2013.01);
Abstract

The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.


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