The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2015
Filed:
Jul. 21, 2012
Ana Pamplona, Lisbon, PT;
Gonçalo J. L. Bernardes, Torres Vedras, PT;
Maria M. Mota, Lisbon, PT;
Carlos C. Romão, Cascais, PT;
Ana Pamplona, Lisbon, PT;
Gonçalo J. L. Bernardes, Torres Vedras, PT;
Maria M. Mota, Lisbon, PT;
Carlos C. Romão, Cascais, PT;
Alfama, Inc., Cambridge, MA (US);
Abstract
The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R, R, R, R, R, X, and Xare as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.