The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 23, 2015

Filed:

Jan. 11, 2011
Applicants:

Nurulain T. Zaveri, Saratoga, CA (US);

Faming Jiang, Mountain View, CA (US);

Inventors:

Nurulain T. Zaveri, Saratoga, CA (US);

Faming Jiang, Mountain View, CA (US);

Assignee:

Astraea Therapeutics, LLC, Mountain View, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/22 (2006.01); A61K 31/44 (2006.01); C07D 221/02 (2006.01); A61K 31/439 (2006.01); C07D 519/00 (2006.01); C07D 451/14 (2006.01);
U.S. Cl.
CPC ...
C07D 451/14 (2013.01); A61K 31/439 (2013.01); C07D 519/00 (2013.01);
Abstract

Provided herein are novel and selective high affinity α3β4 nicotinic acetylcholine receptor ligands and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, drug addiction or pain using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods for modulating a nicotinic acetylcholine receptor (nAChR). In still other embodiments, provided herein are methods of selectively antagonizing receptors such as, for example, the α3β4 nicotinic acetylcholine receptor using the compounds and compositions disclosed herein.


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