The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2015
Filed:
Dec. 08, 2011
Andreas Kling, Ludwigshafen, DE;
Katja Jantos, Ludwigshafen, DE;
Helmut Mack, Ludwigshafen, DE;
Achim Moller, Ludwigshafen, DE;
Wilfried Hornberger, Ludwigshafen, DE;
Yanbin Lao, North Chicago, IL (US);
Gisela Backfisch, Ludwigshafen, DE;
Marjoleen Nijsen, North Chicago, IL (US);
Andreas Kling, Ludwigshafen, DE;
Katja Jantos, Ludwigshafen, DE;
Helmut Mack, Ludwigshafen, DE;
Achim Moller, Ludwigshafen, DE;
Wilfried Hornberger, Ludwigshafen, DE;
Yanbin Lao, North Chicago, IL (US);
Gisela Backfisch, Ludwigshafen, DE;
Marjoleen Nijsen, North Chicago, IL (US);
AbbVie Deutschland GmbH & Co. KG, Wiesbaden, DE;
AbbVie Inc., North Chicago, IL (US);
Abstract
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R, R, R, R, X, m and n have the meanings mentioned in the claims and the description, the tautomers thereof, the hydrates thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein Ris optionally substituted benzyl or hetaryl-methyl, X is a single bond or an oxygen atom, Ris C-C-alkyl, C-C-haloalkyl, C-C-alkenyl, C-C-cycloalkyl, C-C-cycloalkyl-C-C-alkyl, C-C-heterocycloalkyl-C-C-alkyl, phenyl, phenyl-C-C-alkyl, pyridin-2-yl-C-C-alkyl or CH—C(O)OCH, Rand Rindependently of one another are halogen, CN, CF, CHF, CHF, C-C-alkyl or C-C-alkoxy, and m and n independently of one another are 0 or 1.