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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9062013 B1

PDFFull Text
Date of Patent:
Jun. 23, 2015

Filed:

Feb. 02, 2012

Positive allosteric modulators of the α7 nicotinic acetylcholine receptor and uses thereof

Applicants:

Andrew Harvey, Goodwood, AU;

Audrey Fluck, Dangolsheim, FR;

Bruno Giethlen, Altorf, FR;

Dharam Paul, Flinders Park, AU;

Laurent Schaeffer, Durrenentzen, FR;

Inventors:

Andrew Harvey, Goodwood, AU;

Audrey Fluck, Dangolsheim, FR;

Bruno Giethlen, Altorf, FR;

Dharam Paul, Flinders Park, AU;

Laurent Schaeffer, Durrenentzen, FR;

Assignee:

Bionomics Limited, Thebarton, AU;

Attorneys:

Honigman Miller Schwartz & Cohn LLP

Thomas A. Wootton, Esq.

Jonathan P. O'Brien

Primary Examiner:

Zinna Northington Davis

Int. Cl.
CPC ...
C07D 213/75 (2006.01); C07D 231/40 (2006.01); C07D 277/46 (2006.01); C07C 311/46 (2006.01); C07C 233/60 (2006.01); A61K 31/44 (2006.01); A61K 31/167 (2006.01); A61K 31/36 (2006.01); A61K 31/63 (2006.01); C07C 233/59 (2006.01); C07C 311/16 (2006.01); C07D 317/46 (2006.01); C07D 275/06 (2006.01); C07D 209/46 (2006.01);
U.S. Cl.
CPC ...
C07D 277/46 (2013.01); C07C 233/59 (2013.01); C07C 233/60 (2013.01); C07C 311/16 (2013.01); C07C 2101/02 (2013.01); C07C 2102/50 (2013.01); C07D 213/75 (2013.01); C07D 231/40 (2013.01); C07D 317/46 (2013.01); C07C 311/46 (2013.01); C07D 275/06 (2013.01); C07D 209/46 (2013.01);
Abstract

The present invention relates to compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also inflammatory diseases.

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