The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2015
Filed:
Feb. 16, 2011
Yuuki Asuma, Kanagawa, JP;
Tatsuya Suzuki, Kanagawa, JP;
Jun Takehara, Fukuoka, JP;
Tsugihiko Hidaka, Fukuoka, JP;
Kuniko Asada, Tokyo, JP;
Ryoma Miyake, Kanagawa, JP;
Yasumasa Dekishima, Kanagawa, JP;
Hiroshi Kawabata, Tokyo, JP;
Yuuki Asuma, Kanagawa, JP;
Tatsuya Suzuki, Kanagawa, JP;
Jun Takehara, Fukuoka, JP;
Tsugihiko Hidaka, Fukuoka, JP;
Kuniko Asada, Tokyo, JP;
Ryoma Miyake, Kanagawa, JP;
Yasumasa Dekishima, Kanagawa, JP;
Hiroshi Kawabata, Tokyo, JP;
API CORPORATION, Tokyo, JP;
Abstract
It is an object of the present invention to provide a novel method for producing (1R,2S)/(1S,2R)-1-amino-1-alkoxycarbonyl-2-vinylcyclopropane which is useful as a synthetic intermediate of therapeutic agents for hepatitis C and a synthetic intermediate thereof. According to the present invention, when a trans-2-butene derivative having a leaving group at each of the 1- and 4-positions is reacted with a malonic ester in the presence of a base, a specific amount of an alkali metal alkoxide or an alkali metal hydride is used as the base, and further a specific amount of a malonic ester is used to produce a cyclopropane diester, and further, chiral or achiral 1-amino-1-alkoxy-carbonyl-2-vinylcyclopropane and a salt thereof are synthesized using the cyclopropane diester.