The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2015
Filed:
Jul. 14, 2011
Sung Hee Hong, Suwon-si, KR;
Byung Sun Lee, Seoul, KR;
Dae Seong Im, Yogin-si, KR;
Jae Min Lee, Seoul, KR;
Sung Min Bae, Seongnam-si, KR;
SE Chang Kwon, Seoul, KR;
Sung Hee Hong, Suwon-si, KR;
Byung Sun Lee, Seoul, KR;
Dae Seong Im, Yogin-si, KR;
Jae Min Lee, Seoul, KR;
Sung Min Bae, Seongnam-si, KR;
Se Chang Kwon, Seoul, KR;
HANMI SCIENCE CO., LTD, Hwaseong-si, KR;
Abstract
Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.