The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2015
Filed:
Oct. 05, 2010
Jorg Breitenbach, Mannheim, DE;
Bernd Liepold, Dossenheim, DE;
Didier R. Lefebvre, Mundelein, IL (US);
Steffen Bossmann, Altleiningen, DE;
Benedikt Steitz, Speyer, DE;
Peter Hölig, Waechtersbach, DE;
Jorg Breitenbach, Mannheim, DE;
Bernd Liepold, Dossenheim, DE;
Didier R. Lefebvre, Mundelein, IL (US);
Steffen Bossmann, Altleiningen, DE;
Benedikt Steitz, Speyer, DE;
Peter Hölig, Waechtersbach, DE;
BDS Pharma GmbH, Graz, AT;
Abstract
A delivery system for sustained release of a calcium-channel blocking agent is adapted for introduction in the cerebrospinal fluid of a subject. The delivery system comprises a solid dispersion product of a calcium-channel blocking agent in a mixture of a (i) first poly(lactide-co-glycolide) having a molecular weight distribution centered around a first number average molecular weight Mnand a (ii) second poly(lactide-co-glycolide) having a molecular weight distribution centered around a second number average molecular weight Mn, wherein Mnis in the range of from 2000 to 3000 g/mol and the ratio of Mn/Mnis from 1.8 to 3.5. The delivery system is deposited in the vicinity of or adjacent to a blood vessel showing vasospasm or suspected of developing vasospasm.