The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 23, 2015

Filed:

Mar. 19, 2012
Applicants:

Richard H. Ebright, New Brunswick, NJ (US);

David Degen, New Brunswick, NJ (US);

Katherine Y. Ebright, New Brunswick, NJ (US);

Inventors:

Richard H. Ebright, New Brunswick, NJ (US);

David Degen, New Brunswick, NJ (US);

Katherine Y. Ebright, New Brunswick, NJ (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); C12Q 1/18 (2006.01); A61K 38/12 (2006.01); C07D 498/08 (2006.01); A61K 31/15 (2006.01); A61K 31/395 (2006.01); A61K 31/155 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 38/12 (2013.01); C07D 498/08 (2013.01); G01N 2333/91275 (2013.01); C12Q 1/18 (2013.01); A61K 31/15 (2013.01); A61K 31/395 (2013.01); A61K 31/155 (2013.01); A61K 45/06 (2013.01); G01N 33/68 (2013.01);
Abstract

It has been discovered that the Sal target represents a new and promising target for antibacterial drug discovery. The Sal target is distinct from the rifamycin target and from the CBR703 target. This indicates that antibacterial compounds that function through the Sal target should exhibit no, or minimal, cross-resistance with rifamycins and CBR703. This further implies that it should be possible to co-administer antibacterial compounds that function through the Sal target together with a rifamycin, together with CBR703, or together with both a rifamycin and CBR703, in order to achieve additive or synergistic antibacterial effects and in order to suppress or eliminate the emergence of resistance.


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