The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2015
Filed:
Sep. 25, 2013
The General Hospital Corporation, Boston, MA (US);
Chugai Pharmaceutical Co., Ltd., Tokyo, JP;
Thomas J. Gardella, Needham, MA (US);
John T. Potts, Jr., Newton, MA (US);
Masaru Shimizu, Shizuoka, JP;
Fumihiko Ichikawa, Tokyo, JP;
Harald Jüppner, Lexington, MA (US);
Makoto Okazaki, Shizuoka, JP;
The General Hospital Corporation, Boston, MA (US);
Chugai Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a G-protein is correlated with the length of time over which the agonist is effective, independently of its pharmacokinetic properties. The invention also provides PTH- and PTHrP-derived polypeptides.