The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2015
Filed:
Mar. 25, 2011
Yoshihiro Kitamura, Tokyo, JP;
Yoko Shimizu, Tokyo, JP;
Chie Aoki, Hyogo, JP;
Lijuan Yu, Beijing, CN;
Takaji Wakita, Tokyo, JP;
Yoshihiro Kitamura, Tokyo, JP;
Yoko Shimizu, Tokyo, JP;
Chie Aoki, Hyogo, JP;
Lijuan Yu, Beijing, CN;
Takaji Wakita, Tokyo, JP;
THE UNIVERSITY OF TOKYO, Tokyo, JP;
NIHON UNIVERSITY, Tokyo, JP;
INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES, Beijing, CN;
TORAY INDUSTRIES, INC., Tokyo, JP;
JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES, Tokyo, JP;
TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE, Tokyo, JP;
Abstract
An objective of this invention is to provide an HCV strain with a high capacity for virus production in a cell culture system. This invention provides a nucleic acid encoding a polyprotein precursor of the hepatitis C virus JFH1 strain having one or more amino acid substitutions, wherein the polyprotein precursor comprises at least substitution of glutamine at position 862 with arginine, as determined with reference to the amino acid sequence as shown in SEQ ID NO: 2 in the Sequence Listing.