The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2015
Filed:
Dec. 12, 2011
Aleksander S. Popel, Lutherville, MD (US);
Elena V. Rosca, Baltimore, MD (US);
Jacob E. Koskimaki, Baltimore, MD (US);
Corban G. Rivera, Baltimore, MD (US);
Niranjan B. Pandey, White Marsh, MD (US);
Amir P. Tamiz, Silver Spring, MD (US);
Aleksander S. Popel, Lutherville, MD (US);
Elena V. Rosca, Baltimore, MD (US);
Jacob E. Koskimaki, Baltimore, MD (US);
Corban G. Rivera, Baltimore, MD (US);
Niranjan B. Pandey, White Marsh, MD (US);
Amir P. Tamiz, Silver Spring, MD (US);
THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);
Abstract
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models are disclosed. The presently disclosed mimetic peptides also exhibit anti-lymphangiogenic and directly anti-tumorigenic properties.