The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2015
Filed:
Aug. 15, 2006
Applicants:
Asser Sloth Andersen, Herlev, DK;
Lars Hojlund Christensen, Vaerlose, DK;
Inventors:
Asser Sloth Andersen, Herlev, DK;
Lars Hojlund Christensen, Vaerlose, DK;
Assignee:
Novo Nordisk A/S, Bagsvaerd, DK;
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/19 (2006.01); C12N 15/17 (2006.01); C12N 15/63 (2006.01); C12N 1/16 (2006.01); C07K 14/62 (2006.01);
U.S. Cl.
CPC ...
C07K 14/62 (2013.01); C12N 15/63 (2013.01); C12N 1/16 (2013.01);
Abstract
The invention is related to a method for making human insulin analogs by culturing an fungi cell comprising a DNA vector encoding a precursor for human insulin analog, wherein the said precursor comprises a connecting peptide flanked with cleavage sites at both junctions with the A- and the B-chain of the insulin peptide, respectively said cleavage sites being cleaved within the fungi cell allowing the cell to secrete high amount of correctly processed, mature two chain human insulin analog to the culture media.