The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2015
Filed:
Feb. 07, 2013
Vaxinnate Corporation, Cranbury, NJ (US);
Langzhou Song, Cranbury, NJ (US);
Valerian Nakaar, Cranbury, NJ (US);
Albert E. Price, Cranbury, NJ (US);
Lynda G. Tussey, Cranbury, NJ (US);
James W. Huleatt, Cranbury, NJ (US);
Thomas J. Powell, Cranbury, NJ (US);
Robert K. Evans, Cranbury, NJ (US);
VaxInnate Corporation, Cranbury, NJ (US);
Abstract
Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring influenza viral hemagglutinin to form a protein portion. The protein portion includes at least a portion of a globular head, and at least a portion of at least one secondary structure having at least one β-sheet at a bottom of the globular head that causes the globular head to essentially retain its tertiary structure. The protein portion made by the methods of the invention lacks a transmembrane domain, a cytoplasmic domain and an HA2 subunit. A nucleic acid sequence encoding the protein portion is transformed into a prokaryotic host cell.