IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9056859 B1

PDFFull Text
Date of Patent:
Jun. 16, 2015

Filed:

Oct. 24, 2011

Inhibitors of the renal outer medullary potassium channel

Applicants:

Alexander Pasternak, Princeton, NJ (US);

Reynalda K. Dejesus, East Brunswick, NJ (US);

Yuping Zhu, Edison, NJ (US);

Lihu Yang, Edison, NJ (US);

Shawn Walsh, Bridgewater, NJ (US);

Haifeng Tang, Metuchen, NJ (US);

Dooseop Kim, Seoul, KR;

Barbara Pio, Hillsborough, NJ (US);

Aurash Shahripour, Rathway, NJ (US);

Kevin Belyk, Metuchen, NJ (US);

Inventors:

Alexander Pasternak, Princeton, NJ (US);

Reynalda K. deJesus, East Brunswick, NJ (US);

Yuping Zhu, Edison, NJ (US);

Lihu Yang, Edison, NJ (US);

Shawn Walsh, Bridgewater, NJ (US);

Haifeng Tang, Metuchen, NJ (US);

Dooseop Kim, Seoul, KR;

Barbara Pio, Hillsborough, NJ (US);

Aurash Shahripour, Rathway, NJ (US);

Kevin Belyk, Metuchen, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Nicole M. Beeler

Catherine D. Fitch

Primary Examiner:

Emily Bernhardt

Int. Cl.
CPC ...
C07D 257/04 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 495/04 (2006.01); A61K 31/496 (2006.01); C07D 311/76 (2006.01); C07D 311/80 (2006.01); C07D 403/10 (2006.01); C07D 307/88 (2006.01); C07D 311/02 (2006.01); C07D 405/06 (2006.01); C07D 471/08 (2006.01); C07D 487/08 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); A61K 31/496 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 311/76 (2013.01); C07D 311/80 (2013.01); C07D 403/10 (2013.01); C07D 413/12 (2013.01); C07D 471/08 (2013.01); C07D 257/04 (2013.01); C07D 487/08 (2013.01); C07D 495/04 (2013.01); C07D 307/88 (2013.01); C07D 311/02 (2013.01); C07D 405/06 (2013.01);
Abstract

This invention relates to compounds having structural Formula (I); and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir 1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.

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