The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2015
Filed:
Mar. 10, 2011
Applicants:
Johannes Maria Franciscus Gerardus Aerts, Abcoude, NL;
Herman Steven Overkleeft, Leiden, NL;
Inventors:
Johannes Maria Franciscus Gerardus Aerts, Abcoude, NL;
Herman Steven Overkleeft, Leiden, NL;
Assignee:
ACADEMISCH MEDISCH CENTRUM BIJ UNIVERSITEIT VAN AMSTERDAM, Amsterdam, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/34 (2006.01); C07D 303/14 (2006.01); C07K 1/22 (2006.01); G01N 33/68 (2006.01); C07D 203/26 (2006.01); C07D 303/36 (2006.01); C07F 5/02 (2006.01);
U.S. Cl.
CPC ...
C07D 303/14 (2013.01); C07K 1/22 (2013.01); C12Q 1/34 (2013.01); G01N 33/6842 (2013.01); G01N 2333/924 (2013.01); G01N 2500/04 (2013.01); G01N 2800/042 (2013.01); C07D 203/26 (2013.01); C07D 303/36 (2013.01); C07F 5/025 (2013.01);
Abstract
An activity based probe (ABP) comprising a glycosidase inhibitor, and a detection-group. The ABPs of the inventions are used for diagnosing storage disorder for screening of compounds suitable for preventing and/or treating a storage disorder, for monitoring of therapeutic enzymes for lysosomal storage disorders, and for ultra-sensitive visualization of glycosidase-fusion proteins in molecular imaging.