The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 16, 2015

Filed:

Sep. 23, 2011
Applicants:

Steve Kangas, Woodbury, MN (US);

James Feng, Maple Grove, MN (US);

Yen-lane Chen, New Brighton, MN (US);

Maggie Zeng, Maple Grove, MN (US);

Inventors:

Steve Kangas, Woodbury, MN (US);

James Feng, Maple Grove, MN (US);

Yen-Lane Chen, New Brighton, MN (US);

Maggie Zeng, Maple Grove, MN (US);

Assignee:

Boston Scientific Scimed, Inc., Maple Grove, MN (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61L 33/00 (2006.01); A61L 27/54 (2006.01); A61L 29/16 (2006.01); A61L 31/16 (2006.01); A61K 31/337 (2006.01); C09D 5/16 (2006.01); A61F 2/02 (2006.01); A61F 2/00 (2006.01);
U.S. Cl.
CPC ...
A61L 27/54 (2013.01); A61K 31/337 (2013.01); C09D 5/16 (2013.01); A61F 2/02 (2013.01); A61F 2/00 (2013.01); A61L 29/16 (2013.01); A61L 31/16 (2013.01); A61L 2300/416 (2013.01); A61L 2300/63 (2013.01);
Abstract

A medical device having a polymer-free outer surface layer comprising a crystalline drug selected from the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin. The device may be produced by a method comprising the steps of providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; and vapor annealing the drug with a solvent vapor to form crystalline drug; wherein a seed layer of a crystalline form of said drug having a maximum particle size of about 10 μm or less is applied to at least said portion of the outer surface of the device before or after applying the drug solution, but before vapor annealing the amorphous coating.


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