The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 16, 2015

Filed:

May. 19, 2011
Applicants:

Ulrich Hersel, Heidelberg/Hanschuhsheim, DE;

Harald Rau, Heidelberg, DE;

Robert Schnepf, Heidelberg/Dossenheim, DE;

Dirk Vetter, Heidelberg/Neuenheim, DE;

Thomas Wegge, Heidelberg/Ziegelhausen, DE;

Inventors:

Ulrich Hersel, Heidelberg/Hanschuhsheim, DE;

Harald Rau, Heidelberg, DE;

Robert Schnepf, Heidelberg/Dossenheim, DE;

Dirk Vetter, Heidelberg/Neuenheim, DE;

Thomas Wegge, Heidelberg/Ziegelhausen, DE;

Assignee:

ASCENDIS PHARMA A/S, Hellerup, DK;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61F 13/00 (2006.01); A61K 39/00 (2006.01); A61K 39/38 (2006.01); A61K 9/14 (2006.01); A61K 31/785 (2006.01); A61K 31/795 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
A61K 31/785 (2013.01); A61K 31/795 (2013.01); A61K 47/48215 (2013.01); A61K 47/48315 (2013.01); A61K 47/48338 (2013.01);
Abstract

A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.


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