The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2015
Filed:
Aug. 17, 2012
Krishnamani Jayaraman, Bangalore, IN;
Muhammed Majeed, East Windsor, NJ (US);
Jeffrey Reinhardt, Carson City, NV (US);
Kalyanam Nagabhushanam, East Windsor, NJ (US);
Samuel Manoharan Thomas, Bangalore, IN;
Krishnamani Jayaraman, Bangalore, IN;
Muhammed Majeed, East Windsor, NJ (US);
Jeffrey Reinhardt, Carson City, NV (US);
Kalyanam Nagabhushanam, East Windsor, NJ (US);
Samuel Manoharan Thomas, Bangalore, IN;
Sami Labs Limited, Bangalore, IN;
Abstract
A novel, bioavailable and safe stilbenoid 3,5-dimethoxy-3,4'-dihydroxystilbene represented by STR#1 with an unexpected enhanced ability to prevent the accumulation of lipids accompanying the terminal differentiation of adipocytes, thereby inhibiting adipogenesis, and nutraceutical and cosmeceutical compositions comprising 3,5-dimethoxy-3,4′-dihydroxystilbene useful for anti-obesity and anti-cellulite therapy, are disclosed. Further the enhanced SIRT-1 activation ability of 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#1 and 2,3′,5′,6-tetrahydroxy-trans-stilbene represented by STR#II are disclosed. The enhancement of SIRT-1 polypeptide activity of the said compounds is unexpectedly much higher than resveratrol or its natural analog pterostilbene. Sirtuin modulating compositions comprising an orally bioavailable SIRT-1 enhancing compounds (i) 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#I and (ii) 2,3′,5′,6-tetrahydroxy-trans-stilbene represented by STR#II are also disclosed. An additional embodiment, also discloses the enhanced anti-activity of 3,5-dimethoxy-3,4′-dihydroxystilbenes represented by STR#I and compositions thereof.