The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2015
Filed:
May. 03, 2013
Kala Pharmaceuticals, Inc., Waltham, MA (US);
Johns Hopkins University, the, Baltimore, MD (US);
Alexey Popov, Waltham, MA (US);
Elizabeth M. Enlow, Waltham, MA (US);
James Bourassa, Somerville, MA (US);
Colin R. Gardner, Concord, MA (US);
Hongming Chen, Belmont, MA (US);
Laura M. Ensign, Towson, MD (US);
Samuel K. Lai, Carrboro, NC (US);
Tao Yu, Baltimore, MD (US);
Justin Hanes, Baltimore, MD (US);
Ming Yang, Towson, MD (US);
Kala Pharmaceuticals, Inc., Waltham, MA (US);
The John Hopkins University, Baltimore, MD (US);
Abstract
Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.