The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Nov. 11, 2011
Jonathan D. Trumbull, Chicago, IL (US);
Gary A. Gintant, Libertyville, IL (US);
Stanislaw Kantor, Buffalo Grove, IL (US);
Jeffrey Yen Pan, Lake Forest, IL (US);
Gilbert J. Diaz, Mount Prospect, IL (US);
Jonathon Green, Elgin, IL (US);
Zhi Su, Vernon Hills, IL (US);
Jeffrey A. Olson, Libertyville, IL (US);
Jonathan D. Trumbull, Chicago, IL (US);
Gary A. Gintant, Libertyville, IL (US);
Stanislaw Kantor, Buffalo Grove, IL (US);
Jeffrey Yen Pan, Lake Forest, IL (US);
Gilbert J. Diaz, Mount Prospect, IL (US);
Jonathon Green, Elgin, IL (US);
Zhi Su, Vernon Hills, IL (US);
Jeffrey A. Olson, Libertyville, IL (US);
AbbVie Inc., North Chicago, IL (US);
Abstract
A rapid and efficient method and apparatus for detecting electrophysiologic, proarrhythmic, contractile, and other effects of substances such as compounds and drugs in native cellular cardiac preparations, the preparations representing an integrated cell-based pharmacologic response is disclosed. More specifically, a method to (1) rapidly and efficiently detect and verify the effects of chemicals, compounds and drugs on cardiac repolarization, contractility, and excitability using optically based techniques and customized simulation protocols, and (2) rapidly and efficiently screen and select compounds for electrophysiologic and proarrhythmic effects on cardiac myocytes is disclosed.