The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Feb. 22, 2012
Shawn Patrick Grogan, Oceanside, CA (US);
Darryl David D'lima, San Diego, CA (US);
Clifford W. Colwell, Jr., La Jolla, CA (US);
Sungho Jin, San Diego, CA (US);
Shawn Patrick Grogan, Oceanside, CA (US);
Darryl David D'Lima, San Diego, CA (US);
Clifford W. Colwell, Jr., La Jolla, CA (US);
Sungho Jin, San Diego, CA (US);
Scripps Health, San Diego, CA (US);
Abstract
Methods are provided for the three dimensional manipulation of cells, and for the formation of an organized engineered cell tissue. Also provided are the organized engineered cell tissues produced by the methods. In one method, a plurality of magnetically labeled cells are mixed with a cross-linkable hydrogel to form a cell-hydrogel mixture, the at least a portion of the plurality of magnetically labeled cells are manipulated with a magnetic field to arrange the magnetically labeled cells into a specific cellular arrangement, and the hydrogel is crosslinked to form the organized engineered cell tissue. The approach presented herein offers a means to circumvent the deficiencies in the field of regenerative medicine, and allows for the production of organized tissues in situ with specific cellular organizations that mimic the native tissue.