The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Aug. 13, 2012
Soon Jae Park, Daejeon, KR;
Hye-shin Chung, Daejeon, KR;
Sang Mee Lee, Daejeon, KR;
Ji-sun Kim, Daejeon, KR;
Soon Jae Park, Daejeon, KR;
Hye-Shin Chung, Daejeon, KR;
Sang Mee Lee, Daejeon, KR;
Ji-Sun Kim, Daejeon, KR;
ALTEOGEN, INC., Daejeon, KR;
Abstract
A novel alpha-1 antitrypsin variant, a method of preparing the same, and use thereof are provided. The alpha-1 antitrypsin variant has excellent stability in the body and maintains an inhibitory effect on elastase activities because the blood half-life (t) and the area under blood drug concentration vs. time curve (AUC) are remarkably increased by adding an N-glycosylation site in animal cells through amino acid mutation between 1and 25positions of the N-terminus of alpha-1 antitrypsin. Therefore, the alpha-1 antitrypsin variant can be useful in preventing or treating alpha-1 antitrypsin deficiency.