The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Mar. 14, 2013
Applicant:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Inventors:
Richard L. Moss, Madison, WI (US);
Ariel Fernandez, Houston, TX (US);
Assignee:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61P 9/04 (2006.01); A61K 38/08 (2006.01); A61K 38/10 (2006.01); A61K 45/06 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4716 (2013.01); A61K 38/1719 (2013.01); A61K 45/06 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01);
Abstract
The present invention provides for methods of treating and slowing the onset of heart failure. The inventors have determined that myosin binding to unphosphorylated Myosin Binding Protein C (MyBP-C) plays a key role in the diminution of cardiac contractile force and frequency in heart failure. The present invention provides peptide inhibitors of the MyBP-C/myosin interaction, thereby increasing both cardiac contractile force and frequency in the failing heart, as well as in patients not yet exhibiting frank heart failure.