The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Sep. 17, 2009
Applicants:
Kazunori Kataoka, Tokyo, JP;
Nobuhiro Nishiyama, Tokyo, JP;
Yan Lee, Tokyo, JP;
Takehiko Ishii, Tokyo, JP;
Inventors:
Kazunori Kataoka, Tokyo, JP;
Nobuhiro Nishiyama, Tokyo, JP;
Yan Lee, Tokyo, JP;
Takehiko Ishii, Tokyo, JP;
Assignee:
THE UNIVERSITY OF TOKYO, Tokyo, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); C07K 1/113 (2006.01); C07K 1/13 (2006.01);
U.S. Cl.
CPC ...
C07K 1/13 (2013.01); A61K 47/48215 (2013.01); A61K 47/48315 (2013.01);
Abstract
The present invention provides a protein delivery means (e.g., a polyion complex) which allows efficient introduction into cells (particularly into the cytoplasm), is highly stable in serum, and is also widely applicable. The polyion complex of the present invention comprises a cationic polymer having a polycation moiety and a charge-conversional protein whose overall charge is converted from basic or neutral to acidic by a specific charge regulator.