The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Dec. 20, 2010
Andreas Kling, Ludwigshafen, DE;
Katja Jantos, Lugwigshafen, DE;
Helmut Mack, Ludwigshafen, DE;
Achim Möller, Ludwigshafen, DE;
Wilfried Hornberger, Ludwigshafen, DE;
Gisela Backfisch, Ludwigshafen, DE;
Yanbin Lao, Abbott Park, IL (US);
Marjoleen Nijsen, Abbott Park, IL (US);
Andreas Kling, Ludwigshafen, DE;
Katja Jantos, Lugwigshafen, DE;
Helmut Mack, Ludwigshafen, DE;
Achim Möller, Ludwigshafen, DE;
Wilfried Hornberger, Ludwigshafen, DE;
Gisela Backfisch, Ludwigshafen, DE;
Yanbin Lao, Abbott Park, IL (US);
Marjoleen Nijsen, Abbott Park, IL (US);
AbbVie Deutschland GmbH & Co. KG, Wiesbaden, DE;
AbbVie Inc., North Chicago, IL (US);
Abstract
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula I in which R, R, RR, R, m and n have the meanings mentioned in the claims and the description, the tautomers thereof, the hydrates thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein Ris optionally substituted phenyl-C-C-alkyl or hetaryl-C-C-alkyl, Ris optionally substituted aryl, hetaryl, aryl-C-C-alkyl, aryl-C-C-alkenyl or hetaryl-C-C-alkyl, Ris C-C-alkyl, C-C-haloalkyl, C-C-alkenyl, C-C-cycloalkyl, C-C-cycloalkyl-C-C-alkyl, or phenyl-C-C-alkyl, Rand Rindependently of one another are halogen, CF, CHF, CHF, C-C-alkyl or C-C-alkoxy, and m and n independently of one another are 0 or 1.