IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9051296 B1

PDFFull Text
Date of Patent:
Jun. 09, 2015

Filed:

Nov. 16, 2010

Aryl carboxamide derivatives as ttx-s blockers

Applicants:

Tatsuya Yamagishi, Aichi, JP;

Yoshimasa Arano, Aichi, JP;

Mikio Morita, Aichi, JP;

Tadashi Inoue, Aichi, JP;

Inventors:

Tatsuya Yamagishi, Aichi, JP;

Yoshimasa Arano, Aichi, JP;

Mikio Morita, Aichi, JP;

Tadashi Inoue, Aichi, JP;

Assignee:

RaQualia Pharma Inc., Aichi, JP;

Attorney:

Wenderoth, Lind & Ponack, L.L.P.

Primary Examiner:

Paul V Ward

Int. Cl.
CPC ...
A61K 31/435 (2006.01); A01N 43/40 (2006.01); C07D 221/04 (2006.01); C07D 401/06 (2006.01); A61K 31/44 (2006.01); A61K 31/445 (2006.01); A61K 31/4525 (2006.01); A61K 31/4535 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/4745 (2006.01); A61K 31/498 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/5383 (2006.01); C07D 211/46 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/06 (2006.01); C07D 413/06 (2006.01); C07D 417/06 (2006.01); C07D 417/10 (2006.01); C07D 455/04 (2006.01); C07D 471/04 (2006.01); C07D 471/06 (2006.01); C07D 487/04 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/06 (2013.01); A61K 31/435 (2013.01); A61K 31/44 (2013.01); A61K 31/445 (2013.01); A61K 31/4525 (2013.01); A61K 31/4535 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/4745 (2013.01); A61K 31/498 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/5383 (2013.01); C07D 211/46 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/06 (2013.01); C07D 413/06 (2013.01); C07D 417/06 (2013.01); C07D 417/10 (2013.01); C07D 455/04 (2013.01); C07D 471/04 (2013.01); C07D 471/06 (2013.01); C07D 487/04 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01); C07D 513/04 (2013.01);
Abstract

The present invention relates to aryl carboxamide derivatives of formula (I), wherein Aris phenyl; Aris aryl; n is 1-4; X is —O—, —S—, —SO— or —SO—, a prodrug thereof or a pharmaceutically acceptable salt thereof, which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of such disorders and diseases as pain in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases as pain in which voltage gated sodium channels are involved.

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