The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 09, 2015

Filed:

Dec. 27, 2013
Applicant:

Daiichi Sankyo Company, Limited, Chuo-ku, Tokyo, JP;

Inventors:

Narihiro Toda, Kanagawa, JP;

Rieko Takano, Tokyo, JP;

Takeshi Shida, Tokyo, JP;

Takahiro Katagiri, Tokyo, JP;

Mitsuhiro Iwamoto, Chiba, JP;

Shinji Ashida, Chiba, JP;

Mami Yamazaki, Tokyo, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/495 (2006.01); A61K 31/496 (2006.01); C07D 241/04 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07C 59/255 (2006.01); C07D 213/64 (2006.01); C07D 295/135 (2006.01); C07D 403/12 (2006.01); C07D 213/643 (2006.01); C07D 295/155 (2006.01);
U.S. Cl.
CPC ...
C07C 59/255 (2013.01); C07D 213/64 (2013.01); C07D 241/04 (2013.01); C07D 295/135 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C07D 213/643 (2013.01); C07D 295/155 (2013.01);
Abstract

To find a therapeutic and/or prophylactic agent for gastrointestinal disorders and so on, the agent having excellent activity and high safety. A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents an optionally substituted phenylene group; B represents an optionally substituted 4- to 10-membered heterocyclic group, an optionally substituted C6-C10 aryl group, or an optionally substituted C3-C10 cycloalkyl group; Rrepresents a hydrogen atom or a C1-C3 alkyl group; Rrepresents a hydrogen atom or a C1-C3 alkyl group; Rrepresents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, a C1-C3 alkoxy C1-C3 alkyl group, or a C1-C3 hydroxyalkyl group; Rrepresents a hydrogen atom, a C1-C6 alkyl group, or a halogen atom; n represents an integer of 1 to 4; and X represents methylene, —O—, —NH—, —N(C1-C3 alkyl)-, —C(═O)—, —S—, —S(O)—, —S(O)—, or a single bond.


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