The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Jun. 09, 2009
John Michael Beals, Indianapolis, IN (US);
Gordon Butler Cutler, Jr., Deltaville, VA (US);
Ryan John Hansen, Riverton, UT (US);
Shun LI, Carmel, IN (US);
Lianshan Zhang, Carmel, IN (US);
John Michael Beals, Indianapolis, IN (US);
Gordon Butler Cutler, Jr., Deltaville, VA (US);
Ryan John Hansen, Riverton, UT (US);
Shun Li, Carmel, IN (US);
Lianshan Zhang, Carmel, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.