The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Aug. 07, 2012
Applicant:
Mark K. Wedel, Temecula, CA (US);
Inventor:
Mark K. Wedel, Temecula, CA (US);
Assignee:
Atlantic Pharmaceuticals (Holdings) Limited, Essex, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 31/7088 (2006.01); A61K 31/711 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01); A61K 31/7105 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7088 (2013.01); A61K 31/711 (2013.01); A61K 31/7105 (2013.01); C12N 15/1138 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01);
Abstract
Disclosed herein is a method for the sustained amelioration and/or treatment of ulcerative colitis comprising rectal administration of a compound comprising an antisense oligonucleotide having the sequence 5'-GCCCAAGCTGGCATCCGTCA-3′, ISIS 2302. The method results in a decrease in the indications of ulcerative colitis for an extended period (greater than 90 days) after the conclusion of the administration of the composition. The composition is well tolerated and systemic exposure is minimal.