The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Apr. 11, 2011
Applicants:
Peter S. Klein, Wynnewood, PA (US);
Jian Huang, Philadelphia, PA (US);
Inventors:
Peter S. Klein, Wynnewood, PA (US);
Jian Huang, Philadelphia, PA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/28 (2006.01); C12N 5/0789 (2010.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); C12N 5/0647 (2013.01); C12N 2501/04 (2013.01); C12N 2501/415 (2013.01);
Abstract
The present invention provides a therapeutic approach to maintain and expand HSCs in vivo using currently available medications that target GSK-3 and mTOR. The present invention also provides a system and method for the ex vivo culturing of HSCs, where an mTOR inhibitor is combined with a GSK-3 inhibitor within the culturing conditions.