The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
May. 31, 2013
Applicant:
United Therapeutics Corporation, Washington, DC (US);
Inventors:
Assignee:
United Therapeutics Corporation, Silver Spring, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/22 (2006.01); A61K 31/19 (2006.01); A61K 31/235 (2006.01); C07C 59/70 (2006.01); C07C 69/712 (2006.01); C07C 229/08 (2006.01); C07C 235/06 (2006.01); C07C 235/08 (2006.01); C07C 259/06 (2006.01); C07F 9/09 (2006.01); C07F 9/117 (2006.01); C07C 51/41 (2006.01);
U.S. Cl.
CPC ...
A61K 31/235 (2013.01); C07C 59/70 (2013.01); C07C 69/712 (2013.01); C07C 229/08 (2013.01); C07C 235/06 (2013.01); C07C 235/08 (2013.01); C07C 259/06 (2013.01); C07F 9/091 (2013.01); C07F 9/117 (2013.01); C07C 51/412 (2013.01); C07C 2103/10 (2013.01);
Abstract
This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula: