The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Apr. 01, 2008
Applicants:
David A. Zopf, Wayne, PA (US);
Heinz Lubenau, Neustadt, DE;
Inventors:
David A. Zopf, Wayne, PA (US);
Heinz Lubenau, Neustadt, DE;
Assignee:
ratiopharm GmbH, Ulm, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61K 38/00 (2006.01); A61P 7/06 (2006.01); C07K 14/535 (2006.01); A61K 38/19 (2006.01); A61K 9/00 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
A61K 38/193 (2013.01); A61K 9/0019 (2013.01); A61K 47/48215 (2013.01);
Abstract
The present invention provides a glycopegylated G-CSF that is therapeutically active and which has pharmacokinetic parameters and properties that are improved relative to an identical, or closely analogous, G-CSF peptide that is not glycopegylated. Furthermore, the invention provides methods for mobilizing hematopoiesis in a subject, particularly a subject who has received or will receive radiation or chemotherapy treatment. The methods and compositions of the invention can further be used to prevent, alleviate and treat the myelosuppressive effects such therapies.