The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9050298 B1

PDF
Full Text
Expired
Date of Patent:
Jun. 09, 2015

Filed:

May. 27, 2011
Applicant:

Hua Cai, Los Angeles, CA (US);

Inventor:

Hua Cai, Los Angeles, CA (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/435 (2006.01); A61K 38/16 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 31/519 (2006.01); A61K 31/7105 (2006.01); C07K 14/475 (2006.01); C12N 5/077 (2010.01); C12N 5/071 (2010.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/18 (2013.01); A61K 31/519 (2013.01); A61K 31/7105 (2013.01); C07K 14/475 (2013.01); A61K 38/00 (2013.01); C12N 5/0657 (2013.01); C12N 5/0691 (2013.01); C12N 5/0692 (2013.01);
Abstract

Disclosed herein are methods for treating, inhibiting, or reducing ischemia/reperfusion injury of a cardiac tissue; increasing phosphorylation of ERK1/2 and/or eNOS in a cardiac tissue; treating, inhibiting, or reducing loss of NO; treating, inhibiting, or reducing uncoupling of NOS; increasing recoupling of NOS; treating, inhibiting, or reducing loss of DCC protein and mRNA expression in a cardiac tissue; decreasing or reducing the infarct size of a heart resulting from ischemia/reperfusion injury; decreasing or reducing superoxide production by a cardiac tissue caused by ischemia/reperfusion injury; treating, inhibiting, or reducing neointimal formation and restenosis; treating, inhibiting, or reducing apoptosis of mobilized endothelial progenitor cells; or a combination thereof of a blood vessel (such as an artery, a coronary artery, a vein, or a capillary) or a portion of the blood vessel in a subject which comprise the administration of netrin-1.


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Cai, Hua. (2015). Method of treating ischemia/reperfusion injuries to a heart with netrin-1 (U.S. Patent No. 9050298). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9050298

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