The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Nov. 25, 2008
Martin Fussenegger, Mägenwil, CH;
Wilfried Weber, Freiburg im Breisgau, DE;
Ronald Schoenmakers, Rijswijk, NL;
Martin Fussenegger, Mägenwil, CH;
Wilfried Weber, Freiburg im Breisgau, DE;
Ronald Schoenmakers, Rijswijk, NL;
ETH Zurich, Zurich, CH;
Abstract
The invention relates to a pharmaceutical composition comprising a compound preventing EthR from binding to the ethA promoter, for example a compound of formula 1 wherein Ris optionally substituted phenyl or optionally substituted pyridyl; R(CH)wherein n is 1, 2, 3 or 4; Ris CH(CH)wherein m is 0, 1, 2 or 3; Xis O, S, NH, N(CH) or CH; and Xis O, S or NH; in particular 2-phenylethyl butyrate, and a thioamide or thiourea of formula 2 wherein Ris optionally substituted phenyl, optionally substituted pyridyl, optionally substituted indolyl, —NRR; or —NH—N═CH—R; and substituents Rto Rhave the meanings indicated in the description, in particular ethionamide. The pharmaceutical composition is useful, e.g., in the treatment of multidrug-resistant tuberculosis.