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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9046589 B1

PDFFull Text
Date of Patent:
Jun. 02, 2015

Filed:

Oct. 31, 2013

Dynamic mr imaging of patients with breast cancer—establishment and comparison of different analytical methods for tissue perfusion and capillary permeability

Applicants:

Kjell-inge Gjesdal, Ålesund, NO;

Endre Grøvik, Ikomnes, NO;

Inventors:

Kjell-Inge Gjesdal, Ålesund, NO;

Endre Grøvik, Ikomnes, NO;

Assignee:

SUNNMORE MR-KLINIKK AS, Alesund, NO;

Attorney:

Finnegan, Henderson, Farabow, Garrett & Dunner LLP

Primary Examiner:

Elmer Chao

Int. Cl.
CPC ...
G06K 9/00 (2006.01); G01R 33/56 (2006.01); A61B 5/055 (2006.01); A61B 5/00 (2006.01); G01R 33/563 (2006.01); G01R 33/28 (2006.01); G01R 33/48 (2006.01);
U.S. Cl.
CPC ...
G01R 33/5602 (2013.01); A61B 5/055 (2013.01); A61B 5/4312 (2013.01); G01R 33/5601 (2013.01); G01R 33/56366 (2013.01); A61B 5/742 (2013.01); G01R 33/281 (2013.01); G01R 33/4828 (2013.01); G01R 33/5608 (2013.01);
Abstract

The present invention encompasses methods, apparatus, and computer based systems for identifying benign and malignant tumors in tissues such as soft tissues and particularly breast tissue using dynamic contrast-enhanced magnetic resonance imagining (DCE-MRI) and dynamic susceptibility contrast-enhanced magnetic resonance (DSC) imagining of the tumors. Some embodiments encompass the use of two dynamic MRI pulse sequences in intercalating mode during parenteral administration of an MR contrast substance, wherein one of said pulse sequences is optimized for spatial information and the other pulse sequence is adjusted for high temporal solution, the high-temporal dissolved sequence further comprising a double echo-collection sensitive towards both DCE and DSC for generating a number of different biomarker data such as pharmacokinetic biomarker data, descriptive DCE biomarkers and descriptive DSC biomarkers, and subsequently normalizing and comparing said data with corresponding data from corresponding benign and malign tumors, respectively.

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