The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2015
Filed:
Jul. 23, 2010
Miguel Abal Posada, Barcelona, ES;
Andreas Doll, Barcelona, ES;
Antonio Gil Moreno, Barcelona, ES;
Tamara Maes, Barcelona, ES;
Cristina Perez, Barcelona, ES;
Jaume Reventós Puigjaner, Bacelona, ES;
Elisabet Rossell, Barcelona, ES;
Miguel Abal Posada, Barcelona, ES;
Andreas Doll, Barcelona, ES;
Antonio Gil Moreno, Barcelona, ES;
Tamara Maes, Barcelona, ES;
Cristina Perez, Barcelona, ES;
Jaume Reventós Puigjaner, Bacelona, ES;
Elisabet Rossell, Barcelona, ES;
Geadic Biotec, AIE, Barcelona, ES;
Abstract
The invention relates to the surprising finding that biomarkers corresponding to ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1 R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, S0CS2, and DCN are differentially expressed in control samples as compared to samples from patients having endometrial cancer and are therefore useful for detecting endometrial cancer. In particular these biomarkers having excellent sensitivity, specificity, and/or the ability to separate affected from non affected individuals. Furthermore, the inventors found that the differential expression of these biomarkers in primary endometrial cancer tumor tissue is correlated to their expression level in uterine fluid samples as compared to control values. Thus these biomarkers are robust in that they are found to be differentially expressed in several different types of samples from affected individuals.