The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2015
Filed:
Apr. 03, 2008
George Muschler, Cleveland Heights, OH (US);
Tonya Caralla, Lakewood, OH (US);
Vincent Hascall, Cleveland Heights, OH (US);
Ronald Midura, Shaker Heights, OH (US);
George Muschler, Cleveland Heights, OH (US);
Tonya Caralla, Lakewood, OH (US);
Vincent Hascall, Cleveland Heights, OH (US);
Ronald Midura, Shaker Heights, OH (US);
THE CLEVELAND CLINIC FOUNDATION, Cleveland, OH (US);
Abstract
Methods for enriching, detecting, or using adult stem cells through the use of recognition ligands that specifically bind to ECM components retained to the surfaces of adult stem cells are described. An ECM component such as hyaluronan that is retained to the surfaces of adult stem cells when removed from animal tissues can be used to detect a diverse population of adult stem cells based on the nature of the ECM niche region in which the adult stem cells normally reside. For example, a separation method such as magnetic separation can be used to detect and isolate or enrich adult stem cells based on a recognition ligand that is specific for an ECM component that is retained to the surfaces of adult stem cells to a greater degree than to other cells in the population.