The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2015
Filed:
Sep. 30, 2005
Jens Holger Vogel, Richmond, CA (US);
Roberto Giovannini, Neuchatel, CH;
Konstantin B. Konstantinov, Waban, MA (US);
Huong MY Nguyen, San Francisco, CA (US);
Paul Wu, Orinda, CA (US);
Jens Holger Vogel, Richmond, CA (US);
Roberto Giovannini, Neuchatel, CH;
Konstantin B. Konstantinov, Waban, MA (US);
Huong My Nguyen, San Francisco, CA (US);
Paul Wu, Orinda, CA (US);
Bayer Healthcare LLC, Whippany, NJ (US);
Abstract
The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration.