The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2015
Filed:
Jun. 12, 2013
Applicant:
William Marsh Rice University, Houston, TX (US);
Inventors:
Zachary T. Ball, Houston, TX (US);
Rituparna Kundu, Houston, TX (US);
Brian V. Popp, Houston, TX (US);
Dean R. Madden, Hanover, NH (US);
Patrick R. Cushing, Hanover, NH (US);
Assignees:
WILLIAM MARSH RICE UNIVERSITY, Houston, TX (US);
TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 7/00 (2006.01); C07K 14/435 (2006.01); C07H 21/00 (2006.01); C07K 1/107 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
C07K 1/1075 (2013.01); C07K 1/107 (2013.01); A61K 47/48015 (2013.01);
Abstract
Methods for targeting a protein by providing an inhibitor covalently linked to a rhodium(II) complex, introducing the inhibitor to the target protein and allowing the inhibitor and protein to interact. The rhodium(II) complex covalently linked to the inhibitor binds the target protein both inorganically and organically and forms stabilizing secondary contacts between the rhodium(II) complex and the protein.