The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2015
Filed:
Aug. 10, 2012
Chih-yuan Lin, Kinmen County, TW;
Yu Chang, Taipei, TW;
Jen-tsung Wang, Changhua County, TW;
Cheng-fang Hsu, Taoyuan County, TW;
Wei-ti Kuo, Kaohsiung, TW;
Hung-wen Yu, Taoyuan County, TW;
Wuu-jyh Lin, Taoyuan County, TW;
Mei-hui Wang, Taoyuan County, TW;
Chih-Yuan Lin, Kinmen County, TW;
Yu Chang, Taipei, TW;
Jen-Tsung Wang, Changhua County, TW;
Cheng-Fang Hsu, Taoyuan County, TW;
Wei-Ti Kuo, Kaohsiung, TW;
Hung-Wen Yu, Taoyuan County, TW;
Wuu-Jyh Lin, Taoyuan County, TW;
Mei-Hui Wang, Taoyuan County, TW;
Atomic Energy Council—Institute of Nuclear Energy Research, Taoyuan County, TW;
Abstract
A method for preparing a precursor used to label hepatocyte receptors is revealed. The precursor contains a bifunctional structure including trisaccharide and DTPA ligand. During synthesis processes of the precursor, silica gel columns and Reverse phase-18 (RP-18) columns are used for purification. Thus both the purification times and cost of each purification are reduced. Moreover, use diethyl ether to facilitate precipitation of products and remove a part of coupling reagent. Removing the coupling reagent helps purification of products. Furthermore, N,N-bis(carboxymethyl)-L-lysine hydrate and benzyl chloroformate are coupled to form a trisaccharide skeleton so as to ensure the yield rate of trisaccharide structure.