The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2015
Filed:
Jul. 12, 2013
The Brigham and Women's Hospital, Inc., Boston, MA (US);
The General Hospital Corporation, Boston, MA (US);
Paul B. Yu, Boston, MA (US);
Gregory D. Cuny, Houston, TX (US);
Kenneth D. Bloch, Chestnut Hill, MA (US);
Randall T. Peterson, Belmont, MA (US);
Charles C. Hong, Nolensville, TN (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
The present invention provides pyridinyl-substituted pyrazolyl pyrimidine small molecule inhibitors of bone morphogenetic protein (BMP) signaling having the structure of formula (I), wherein variables A, B, E, F, X, Y, Z, Ar, L, Rand Rare as defined in the specification. The compounds of the invention are useful in modulating cell growth, differentiation, proliferation, and apoptosis, and thus are useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.