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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9045461 B1

PDFFull Text
Date of Patent:
Jun. 02, 2015

Filed:

Mar. 26, 2014

Phenyl-heteroaryl derivatives and methods of use thereof

Applicant:

Transtech Pharma, Llc, High Point, NC (US);

Inventors:

Devi R. Gohimukkula, Jamestown, NC (US);

David Jones, Milford, OH (US);

Ghassan Qabaja, Jamestown, NC (US);

Jeff J. Zhu, Winston-Salem, NC (US);

Jeremy T. Cooper, High Point, NC (US);

William K. Banner, Greensboro, NC (US);

Kurt Sundermann, Summerfield, NC (US);

Muralidhar Bondlela, Greensboro, NC (US);

Mohan Rao, Greensboro, NC (US);

Pingzhen Wang, Kernersville, NC (US);

Raju B. Gowda, Oak Ridge, NC (US);

Robert C. Andrews, Jamestown, NC (US);

Suparna Gupta, Greensboro, NC (US);

Anitha Hari, High Point, NC (US);

Rongyuan Xie, Greensboro, NC (US);

Assignee:

TransTech Pharma, LLC, High Point, NC (US);

Attorney:

Samuel B. Rollins

Primary Examiner:

Alexander R Pagano

Int. Cl.
CPC ...
A61K 31/50 (2006.01); A61K 31/501 (2006.01); C07D 401/12 (2006.01); C07D 237/14 (2006.01); C07D 237/24 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/14 (2006.01); C07D 413/06 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 451/06 (2006.01); C07D 453/02 (2006.01); C07D 471/04 (2006.01); A61K 31/497 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 31/497 (2013.01); C07D 237/14 (2013.01); C07D 237/24 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/14 (2013.01); C07D 413/06 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 451/06 (2013.01); C07D 453/02 (2013.01); C07D 471/04 (2013.01);
Abstract

The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof These compounds are useful in the treatment of RAGE-mediated diseases. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.

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