The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2015
Filed:
May. 30, 2013
Applicants:
Mathai Mammen, Menlo Park, CA (US);
Adam D. Hughes, Belmont, CA (US);
Inventors:
Mathai Mammen, Menlo Park, CA (US);
Adam D. Hughes, Belmont, CA (US);
Assignee:
Theravance Biopharma R&D IP, LLC, South San Francisco, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 261/18 (2006.01); C07D 413/12 (2006.01); C07D 271/08 (2006.01); C07C 235/80 (2006.01); A61K 31/42 (2006.01); A61K 31/4245 (2006.01); A61K 31/216 (2006.01); C07C 233/56 (2006.01); A61K 45/06 (2006.01); C07D 271/04 (2006.01); C07C 243/28 (2006.01);
U.S. Cl.
CPC ...
C07D 271/08 (2013.01); C07C 233/56 (2013.01); C07D 261/18 (2013.01); A61K 31/42 (2013.01); A61K 45/06 (2013.01); C07D 413/12 (2013.01); A61K 31/4245 (2013.01); A61K 31/216 (2013.01); C07D 271/04 (2013.01); C07C 235/80 (2013.01); C07C 243/28 (2013.01);
Abstract
In one aspect, the invention relates to compounds having the formula: where R, R, R, R, R, Z, X, b, and c are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are nitric oxide donors and have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.